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One of the reasons for the failure of Protestantism to make any inroads in Italy was because of persecution by the Catholic Church, usually with the support of the local rulers. The Church in Italy was corrupt but it was also powerful. Since the early middle ages, the Inquisition had not been very active. In general, the humanists had been able to hold many unorthodox views and opinions. The threat of Protestantism meant that the Inquisition was reformed and became much more active.<ref> Burman, Edward, <i>[https://www.amazon.com/gp/product/075093722X/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=075093722X&linkCode=as2&tag=dailyh0c-20&linkId=af2dfafe7050e8affa7882857fef9494 The Inquisition: The Hammer of Heresy]</i> (London, Sutton Publishers, 2004), p 67, 78</ref> The Inquisition was a series of institutions that were dedicated to ensuring religious conformity and to the eradication of any heretical beliefs. Soon the Inquisition was searching out for Protestants and arresting them. Those who were suspected of holding views that were sympathetic to Protestantism were deemed to be heretics. They were placed often in special prisons, tortured and tried in Church courts. Protestants, if found guilty of heresy , could be sentenced to death. Many Protestants were executed in brutal ways.

Bartolomeo Fonzio, who translated some Protestant tracts into Italian, was executed by drowning and more were burnt at the stake. These executions all took place in public and the Italian population was left in no with little doubt of about the dangers of even sympathizing with the Protestant cause. The Church in Italy was able to prevent the spread of Lutheran or other Protestant ideas unlike in Northern Europe.<ref>Burman, p 113</ref> The Roman Catholic Hierarchy was able to suppress the teachings and the writings of the reformers. There was no discussion of the ideas of Luther or Calvin in the Universities of Italy. The Church was able to introduce a system of censorship that prevented Protestant literature and writings from reaching many Italians. The also operated an elaborate surveillance system: agents of the church would check people’s letters and ensured that the printing presses only produce works that conformed to Catholic teaching.<ref>Burman, p. 115</ref> Preaching was very important in the spread of Reformation but this was impossible in Italy. Any Italian or foreign Protestant who preached in Italy was liable to be arrested by the Inquisition.