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What were the contributions of the de Medici family to the Renaissance in Italy during the fifteenth century? The de Medicis were the effective rulers of the Florentine Republic in the 15th century, and they later became the ruling house of Florence in the 16th and 17th century. The family, especially in the fifteenth century made a decisive contribution to the Renaissance in Italy.  This contribution was through their patronage of the arts in their native Florence and their policies that favored peace and stability in Italy. The de Medicis made a real and telling contribution to the arts, politics, and stability of Italy and encouraged the intellectual and cultural flourishing that became known as the Renaissance.