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The Italian Renaissance was one of the most exciting periods in human civilisation. It witnessed a great flourishing of the arts, literature, philosophy, architecture and politics. Many of the greatest figures in World Civilisation appeared during the Renaissance in Italy, including Michelangelo, Leonardo Da Vinci, Machiavelli and Raphael. The Renaissance’s days of glories occurred from approximately 1400-1500. However, several factors led to the end of the Renaissance and the end of one of the most creative periods in human history. This article will demonstrate the reasons why the Italian Renaissance ended.